Preheat your oven to 350°F and line a baking sheet with parchment paper. While the oven heats, measure out all your ingredients into small bowls: cottage cheese, parmesan, mozzarella, pepperoni, pizza sauce, and the dry seasonings (italian seasoning, garlic powder, onion powder, salt, and pepper). Having everything ready before you start ensures a smooth, efficient assembly process.
In a bowl, combine the cottage cheese with the parmesan cheese, italian seasoning, garlic powder, onion powder, salt, and pepper. Mix until everything is evenly incorporated and the seasonings are well distributed throughout. Spread this mixture onto your prepared parchment paper in a circular pizza shape, roughly 10-12 inches in diameter. I like to use the back of a spoon or spatula to create an even thickness—about ¼ inch thick works best for a sturdy but tender crust.
Place the baking sheet in your preheated 350°F oven and bake for 35 minutes. During this time, the cottage cheese will set and firm up, creating a sturdy foundation for your toppings. The crust should be lightly golden and cooked through when finished. I find that this initial bake is crucial—it prevents the crust from being too wet when you add the sauce and cheese.
Remove the partially baked crust from the oven. Spread the pizza sauce evenly over the surface, leaving a small border around the edges. Sprinkle the shredded mozzarella cheese over the sauce, then distribute the pepperoni slices evenly across the top. Be generous with the toppings—they'll add flavor and help create those delicious crispy edges.
Return the pizza to the oven and bake for 5-10 minutes, until the cheese is melted and bubbly and the pepperoni edges are slightly crispy. Remove from the oven and let cool for 2-3 minutes before slicing. This short rest allows the cheese to set slightly, making it easier to cut and serve clean slices.